Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils-其他重组蛋白-深圳欣博盛生物科技有限公司

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Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils

品牌：Stressmarq

官网链接

说明书

折扣/货期

货号：SPR-504XE

规格：500 µg (@5mg/ml)

目录价：￥20664

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils

别名:

Alpha synuclein protein, Alpha-synuclein protein, Non-A beta component of AD amyloid protein, Non-A4 component of amyloid precursor protein, NACP protein, SNCA protein, NACP protein, PARK1 protein, SYN protein, Parkinson's disease familial 1 Protein, Alpha Synuclein TNG

产品描述:

Human Recombinant Alpha Synuclein TNG (A53T, S87N, N103G) Mutant Pre-formed Fibrils

反应种属:

Human

实验应用:

WB | In vivo Assay | In vitro Assay

纯化方式:

Ion-exchange Purified

偶联:

No Tag

产品浓度:

2 mg/ml or 5 mg/ml

表达系统:

E. coli

保存温度:

-80ºC

运输温度:

Dry Ice. Shipping note: Product will be shipped separately from other products purchased in the same order.

预期分子量:

14.46 kDa

存储溶液:

1X PBS pH7.4

产地:

加拿大

功能与背景:

Human alpha synuclein TNG mutant (HuTNG) is a triple mutant containing Ala53 mutated to the equivalent mouse residue Thr53, Ser87 mutated to the equivalent mouse residue Asn87, and Asn103 mutated to the equivalent mouse residue Gly103, effectively making it a human-mouse chimeric protein. Despite sequence differences at only seven residues, or 5% of the total 140 amino acids, the aggregation rate of wild-type mouse α-syn (MsWT) is faster than wild-type human α-syn (HuWT) in vitro. In wild-type mouse models, MsWT fibrils are more efficient than HuWT fibrils at inducing endogenous mouse α-syn pathology (1). A53T or S87N substitutions in human α-syn substantially accelerate fibrilization rates in vitro (2,3). Chimeric HuTNG fibrils show enhanced induction of α-syn pathology greater than both HuWT and MsWT fibrils after single unilateral injection into the dorsal striatum in mice (4). Therefore, HuTNG is a good construct for inducing robust endogenous α-syn seeding and pathology in wild-type mice.

纯度:

>95%

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