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折扣/货期| 货号：REV-31-1407-00-R100 | 规格：100 ul | 目录价：￥5558 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
anti-VEGFR2 (human), Rabbit Monoclonal (RM515)
别名:
Vascular Endothelial Growth Factor Receptor 2; Kinase Insert Domain Receptor; Protein-tyrosine Kinase Receptor Flk-1; CD309; KDR; FLK-1
产品描述:
Disruption of the precise balance of positive and negative molecular regulators of blood and lymphatic vessel growth can lead to myriad diseases. Although dozens of natural inhibitors of hemangiogenesis have been identified, an endogenous selective inhibitor of lymphatic vessel growth has not been previously described. A splice variant of the gene encoding vascular endothelial growth factor receptor-2 (VEGFR-2) that encodes a secreted form of the protein, designated endogenous soluble VEGFR-2 (esVEGFR-2/KDR) has been described. The endogenous soluble esKDR inhibits developmental and reparative lymphangiogenesis by blocking VEGF-C function. Tissue-specific loss of esKDR in mice induced, at birth, spontaneous lymphatic invasion of the normally alymphatic cornea and hyperplasia of skin lymphatics without affecting blood vasculature. Administration of esKDR inhibited lymphangiogenesis but not hemangiogenesis induced by corneal suture injury or transplantation, enhanced corneal allograft survival and suppressed lymphangioma cellular proliferation. Naturally occurring esKDR thus acts as a molecular uncoupler of blood and lymphatic vessels; modulation of esKDR might have therapeutic effects in treating lymphatic vascular malformations, transplantation rejection and, potentially, tumor lymphangiogenesis and lymphedema.
宿主来源:
Rabbit
实验应用:
IHC, WB
靶标/特异性:
This antibody reacts to human VEGFR2 (KDR; FLK-1; CD309).
同种型:
Rabbit IgG
免疫原:
A peptide corresponding to residues near the C-terminus of human VEGFR2.
克隆号:
RM515
保存温度:
+4°C
运输温度:
BI
产品形式:
liquid
存储溶液:
Liquid. 50% Glycerol/PBS with 1% BSA and 0.09% sodium azide.
有效期:
Stable for at least 1 year after receipt when stored at -20°C.
产地:
瑞士
纯度:
Protein A purified.
促销活动
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