深圳欣博盛生物科技有限公司

Promise  Proteomics is a pioneer and expert in mass spectrometry-basedquantification   methods development and in bioproduction of Stable Isotope Labelled (SIL) proteins

                                                   Why using our   SIL-Protein ?

Our   SIL-proteins are the gold standard forquantitative LC-MS.

Characteristics

SIL-Proteins   correct bias occuring duringthe preparation and analytical workflowand due to   losses, incomplete digestion,adsorption, proteolysis... With SIL-Proteins,the   accuracy and reproducibility of yourquantification data is improved.

✮ Full length recombinant proteins
  ✮ Identical   to the protein of interest,
      same sequence as native protein
  ✮ High   isotopic incorporation,stability and purity
  ✮ Uniform   or specific labelling,
      13C,15N isotope
  ✮ Unlabelled   option

This product is useful for :
  ✮ Bioanalysis   pharmacokinetics studies(clinical & nonclinical),
  ✮ Research   and Discovery/pre-clinical/clinical drug development
  ✮ Biomarker's   quantification

                                                                  How to use it ?

Unlike the   use of SIL-peptides, Promise’s SIL-proteins are processed along with   thetarget analytes throughout the pre-analytical
  and LC-MS workflow.

Neuroscience/Psychiatric diseases biomarkers

Apolipoprotein E3

U15N

Neurofilament

(Arg,Lys) 13C15N

Synuclein alpha

(Arg,Lys) 13C15N

Synuclein beta

U15N

Synuclein gamma

U15N

Tau 441

(Arg,Lys) 13C15N

Tau 352

U15N

Cardiovascular disease biomarkers

Apolipoprotein A1

U15N

Carboxypeptidase B2

(Arg,Lys) 13C15N

Clusterin protein

(Arg,Lys) 13C15N

NT-proBNP

U15N

Troponin I

U15N

Metabolic biomarkers

Albumin

U15N

Cystatin C

U15N

Erythropoietin

(Arg,Lys) 13C15N

Growth hormone 22

U15N

Vitamin D binding Protein

(Arg,Lys) 13C15N

Cancer biomarkers

Alpha Feto Protein

(Arg,Lys) 13C15N

Choriogonadotropin

(Arg,Lys) 13C15N

KRAS 2A

U15N

KRAS 2B G12C mutant

(Arg,Lys) 13C15N

KRAS 2B G12C/C118A mutant

KRAS 2B 12C/C51S/C80L/C118S

KRAS 2B G12D mutant

(Arg,Lys) 13C15N

KRAS 2B G13C mutant

(Arg,Lys) 13C15N

KRAS 2B G13D mutant

(Arg,Lys) 13C15N

NRAS

U15N

Sepsis biomarker

Procalcitonin

U15N

Neuroscience/Psychiatric diseases biomarkers

Apolipoprotein E3

✔

U15N

✔

Neurofilament

✔

(Arg,Lys) 13C15N

✔

Synuclein alpha

✔

(Arg,Lys) 13C15N 

✔

Synuclein beta

U15N

✔

Synuclein gamma

U15N 

✔

Tau 441

✔

(Arg,Lys) 13C15N

✔

Tau 352

U15N 

✔

Cardiovascular disease biomarkers

Apolipoprotein A1

✔

U15N 

✔

Carboxypeptidase B2

(Arg,Lys) 13C15N 

✔

Clusterin protein 

(Arg,Lys) 13C15N 

✔

NT-proBNP

✔

U15N 

✔

Troponin I

U15N 

✔

Metabolic biomarkers

Albumin

U15N

✔

Cystatin C

✔

U15N 

✔

Erythropoietin

(Arg,Lys) 13C15N

✔

Growth hormone 22

✔

U15N

✔

Vitamin D binding Protein

(Arg,Lys) 13C15N

✔

Cancer biomarkers

Alpha Feto Protein

(Arg,Lys) 13C15N

✔

Choriogonadotropin

(Arg,Lys) 13C15N

✔

KRAS 2A

✔

U15N

✔

KRAS 2B G12C mutant

✔

(Arg,Lys) 13C15N

✔

KRAS 2B G12C/C118A mutant

✔

KRAS 2B 12C/C51S/C80L/C118S

✔

KRAS 2B G12D mutant 

(Arg,Lys) 13C15N

✔

KRAS 2B G13C mutant

(Arg,Lys) 13C15N

✔

KRAS 2B G13D mutant

(Arg,Lys) 13C15N

✔

NRAS

✔

U15N

✔

Sepsis biomarker

Procalcitonin

✔

U15N

✔

Albumin - Labelled U15N

https://promise-proteomics.com/product/15n-labelled-albumin

Alpha Feto Protein - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/alpha-foeto-protein-afp13c15n

APO A1 - Labelled U15N

https://promise-proteomics.com/product/vitamin-d-biding-protein-13c15n-2

APO A1 - Unlabelled

https://promise-proteomics.com/product/human-apo-a1-light

APO E3 - Labelled U15N

https://promise-proteomics.com/product/vitamin-d-biding-protein-13c15n-2-2

APO E3 – Unlabelled

https://promise-proteomics.com/product/human-apo-eiii-light

Carboxypeptidase B2 - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/carboxypeptidase-b2-cpb2-13c15n

Choriogonadotropin - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/choriogonadotropin-labelled

Clusterin protein - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/human-clusterin-protein-13c15n

Cystatin C - Labelled U15N

https://promise-proteomics.com/product/cystatin-c-15n

Cystatin C - Unlabelled

https://promise-proteomics.com/product/cystatin-c-light

Erythropoietin - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/human-erythropoietin-epo-13c15n

Growth hormone 22 - Labelled U15N

https://promise-proteomics.com/product/labelled-growth-hormone-22-u15n

Growth Hormone 22 - Unlabelled

https://promise-proteomics.com/product/growth-hormone-22-light

KRAS 2B G12C mutant - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/human-kras-13c15n

KRAS 2B G12C mutant - Unlabelled

https://promise-proteomics.com/product/human-kras-g12c-mutant-light

KRAS 2B G12C/C118A mutant - Unlabelled

https://promise-proteomics.com/product/kras-g12c-c118a-mutant-unlabelled

KRAS 2B G12C/C51S/C80L/C118S - Unlabelled

https://promise-proteomics.com/product/kras-2b-g12c-c51s-c80l-c118s-unlabelled

Human KRAS 2B G12D

mutant  - Labelled (Arg, Lys) 13C15N

https://promise-proteomics.com/product/kras-2b-g12d-mutant-labelled-arglys-13c15n

Human KRAS 2B G13C

mutant - Labelled (Arg, Lys) 13C15N

https://promise-proteomics.com/product/kras-2b-g13c-mutant-labelled-arglys-13c15n

KRAS 2B G13D mutant - Labelled (Arg, Lys) 13C15N

https://promise-proteomics.com/product/kras-2b-g13d-mutant-labelled-arglys-13c15n

KRAS 2A - Labelled U15N

https://promise-proteomics.com/product/kras-2a-labelled-u15n

KRAS 2A - Unlabelled

https://promise-proteomics.com/product/kras-2a-unlabelled

NRAS - Labelled U15N

https://promise-proteomics.com/product/nras-labelled-u15n

NRAS - Unlabelled

https://promise-proteomics.com/product/nras-unlabelled

KRAS 2B – Unlabelled

https://promise-proteomics.com/product/kras-2b-unlabelled

Neurofilament - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/vitamin-d-biding-protein-13c15n

Neurofilament - Unlabelled

https://promise-proteomics.com/product/human-neurofilament-light

NT-proBNP - Labelled U15N

https://promise-proteomics.com/product/nt-probnp-labelled-arglys-13c15n-2

NT-proBNP - Unlabelled

https://promise-proteomics.com/product/nt-probnp-labelled-arglys-13c15n

Procalcitonin - Labelled U15N

https://promise-proteomics.com/product/procalcitonin-pct-u15n

Procalcitonin - Unlabelled

https://promise-proteomics.com/product/procalcitonin-pct-light

Synuclein alpha - Labelled (Lys) 13C15N

https://promise-proteomics.com/product/synuclein-13c15n

Synuclein alpha - Unlabelled

https://promise-proteomics.com/product/synuclein-light

Synuclein beta - Labelled U15N

https://promise-proteomics.com/product/synuclein-beta-labelled-u15n

Synuclein gamma - Labelled U15N

https://promise-proteomics.com/product/synuclein-gamma-labelled-u15n

Tau 441 - Labelled (Arg,Lys) 13C15N

https://promise-proteomics.com/product/tau-13c15n

Tau 441 - Unlabelled

https://promise-proteomics.com/product/tau-light

Tau 352- Labelled U15N

https://promise-proteomics.com/product/tau-352-labelled-u15n

Troponin I - Labelled U15N

https://promise-proteomics.com/product/human-troponin-i-15n

Vitamin D binding Protein -Labelled (Arg, Lys) 13C15N

https://promise-proteomics.com/product/human-kras-13c15n-2