BIoXCell新品推荐:InVivoSIM anti-human EGFR(Panitumumab Biosimilar)
InVivoSIM anti-human EGFR(Panitumumab Biosimilar)
产品中文名称:InVivoSIM 抗人 EGFR (Panitumumab 生物仿制药)抗 体,克隆:Panitumumab(目录 号#SIM0050)
Key features:
▲ Panitumumab is a humanized IgG2κ antibody against epidermal growth factor receptor (EGFR).
▲ EGFR belongs to the HER tyrosine kinase growth factor receptor family (EGFR/HER1/erbB1, HER2/erbB2, HER3/erbB3, and HER4/erbB4).
▲ EGFR binds its ligands (EGF, TGF, AREG, EPGN, BTC, EREG, etc.) and is involved in several pathways, including RAS-RAFMEK-ERK, PI3 kinase-AKT, PLCγ-PKC, STAT modules, and NF-κB.
▲ Panitumumab antibody bind EGFR more strongly than EGFR's ligands, and EGFR neutralization leads to cell cycle arrest and inhibition of tumor growth.
Application: in vivo neutralization of human EGFR, in vitro neutralization of human EGFR, ELISA, Western blot
cytometry Research Area: Cancer Biology, Apoptosis, Tumor Antigen, Cell Migration and Adhesion
Related targets: HER2/erbB2, TGF-β, PSMA, PD1, AREG (coming soon)
主要特点:
▲ Panitumumab 是一种针对表皮生长 因子受体(EGFR)的重组人源化 IgG2κ 抗体。
▲ EGFR 属于 HER 酪氨酸激酶生长因子 受体家族(EGFR/HER1/erbB1, HER2/erbB2, HER3/erbB3, 和 HER4/erbB4)。
▲ EGFR 与其配体结合(如 EGF, TGF, AREG, EPGN, BTC, EREG 等),参与多 个信号通路,包括 RAS-RAF-MEKERK, PI3 激酶-AKT, PLCγ-PKC, STAT 模 块和 NF-κB。
▲ Panitumumab 抗体与 EGFR 的结合力 比 EGFR 的配体更强,中和 EGFR 可 导致细胞周期停滞并抑制肿瘤生长。
应用:体内中和人 EGFR,体外中和人 EGFR, ELISA,Western blot
研究领域:癌症生物学、细胞凋亡、肿瘤抗原、细胞迁 移与黏附
相关靶点:HER2/erbB2, TGF-β, PSMA, PD1, AREG(即将 推出)
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