Colchicine-其他小分子化合物-深圳欣博盛生物科技有限公司

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Colchicine

品牌：Adipogen

官网链接

说明书

折扣/货期

货号：AG-CN2-0048-G001	规格：1 g	目录价：￥1440
货号：AG-CN2-0048-M500	规格：500 mg	目录价：￥840

产品详情

* 以下信息仅供参考，详情请以原厂网站为准

产品名称:

Colchicine

别名:

NSC 757; EINECS 200-598-5

产品描述:

Anti-cancer compound [5]. Microtubule assembly inhibitor. Depolymerizes microtubules and limits microtubule formation (inactivates spindle fibre formation) [1, 2, 5, 6]. Inhibits mitosis during cell division at metaphase by inhibiting spindle formation [6]. Anti-inflammatory compound [7, 9]. Suppresses monosodium urate crystal-induced NLRP3/NALP3 inflammasome-driven caspase-1 activation, IL-1beta processing and release, and L-selectin expression on neutrophils at micromolar concentrations. Blocks the release of a crystal-derived chemotactic factor from neutrophil lysosomes, blocks neutrophil adhesion to, and inhibits monosodium urate crystal-induced production of superoxide anions from neutrophils at nanomolar concentrations [7]. Drug used in treatment of gout, familial Mediterranean fever, pericarditis and Behect's disease. Investigated for its anti-cancer activity [5, 8, 9]. It has a narrow therapeutic index with no clear-cut distinction between nontoxic, toxic and lethal doses, causing substantial confusion among clinicians [8]. Apoptosis inducer in a variety of normal and tumor cell lines [3, 4]. Inhibitor of autophagosome-lysosome fusion. Inhibits acetylated a-tubulin mediated dynein dependent transport of mitochondria and subsequent apposition of ASC on mitochondria to NLRP3 on the endoplasmic reticulum in vitro and in vivo.

宿主来源:

Isolated from Colchicum autumnale.

保存温度:

+4°C

运输温度:

Ambient

预期分子量:

399.4

产品形式:

solid

有效期:

Stable for at least 2 years after receipt when stored at -20°C.