官网链接
折扣/货期| 货号：AG-CN2-0047-M001 | 规格：1 mg | 目录价：￥180 |
| 货号：AG-CN2-0047-M005 | 规格：5 mg | 目录价：￥300 |
| 货号：AG-CN2-0047-M025 | 规格：25 mg | 目录价：￥1320 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
FK-506 [Tacrolimus]
别名:
Tacrolimus; Fujimycin
产品描述:
Potent immunosuppressant (as cyclosporin A and rapamycin) [1-3]. Suppresses proliferation of cytotoxic T cells and inhibits the production of T cell-derived mediators such as interleukin-2 (IL-2) [2, 4]. Forms a complex with FK-506 binding protein 12 (FKBP12). Inhibits the activity of the calcium/calmodulin-dependent protein phosphatase 2B (PP2B; calcineurin), leading to disruption of T cell activation [2, 4, 6, 7]. Prevents rejection of transplanted organs [3]. Anti-inflammatory compound in the treatment of several inflammatory skin diseases (e.g. atopic dermatitis) and with potential anti-rheumatic activity (rheumatoid arthritis) [5, 9]. Neuroprotective. Regulates nitric oxide neurotoxicity. Neurotransmitter. Ca2+ release compound [8]. NF-kappaB suppressor by induction of unfolded protein response (UPR) [11]. Anti-cancer compound. Apoptosis inducer [10, 12].
宿主来源:
Isolated from Streptomyces tsukubaensis.
保存温度:
+4°C
运输温度:
Ambient
预期分子量:
804.0 . 18.0
产品形式:
solid
有效期:
Stable for at least 2 years after receipt when stored at -20°C.
产地:
瑞士
纯度:
>98% (HPLC)
CAS号:
109581-93-3
分子式:
C44H69NO12 . H2O
溶解度:
Soluble in DMSO, ethanol, methanol, ethyl acetate or acetone. Insoluble in water.
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