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折扣/货期| 货号：SBB-PP0004-C025 | 规格：25 ug | 目录价：￥5754 |
产品详情
* 以下信息仅供参考，详情请以原厂网站为准
产品名称:
20S Immunoproteasome (human) (untagged)
产品描述:
The 20S immunoproteasome is structurally similar to constitutive 26S proteasome. The 20S core of immunoproteasome contains two outer rings composed of alpha-subunits, and two internal 7-subunit containing rings each possessing 3 specific subunits responsible for proteasome catalytic activity. In immunoproteasomes these subunits (ß1, ß2, ß5) are replaced by three inducible subunits: PSMB9, PSMB10 and PSMB8, (ß1i, ß2i, ß5i). These stress-induced subunits allow for the production of MHC-1 associating peptides, which are displayed as antigens on the cell surface. These displayed peptides can then be recognized by immune surveillance CD8 T cells. 20S immunoproteasome is recognized as a strong drug target for autoimmune disease and cancer.
宿主来源:
Human PBMCs
产品浓度:
Lot dependent.
保存温度:
-80°C
运输温度:
Dry Ice
预期分子量:
~700kDa
产品形式:
liquid
存储溶液:
Liquid. In 50mM HEPES pH 7.5, 100mM sodium chloride, 1mM TCEP.
有效期:
Stable for at least 1 year after receipt when stored at -80°C.
纯度:
>95% (SDS-PAGE)
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